At the core of DBI’s work lies scientific research on how breath analysis can improve diagnosis and patient treatment.

Publications

Based on our technology, several relevant studies and investigations have been published during the past years.

Key Reference Publications

Journal of Breath Research - iopscience, 2023

Prediction of systemic free and total valproic acid by off-line analysis of exhaled breath in epileptic children and adolescents

Mo Awchi, Kapil Dev Singh, Patricia E. Dill, Urs Frey, Alexandre N. Datta, and Pablo Sinues

Publication

Lung Cancer Journal, 2022

Mapping the landscape of lung cancer breath analysis: A scoping review

Felix Schmidt, Dario Kohlbrenner, Stefan Malesevic, Alice Huang, Sabine D. Klein, Milo A. Puhan, Malcolm Kohler

Publication

Cells, 2022

Validating Discriminative Signatures for Obstructive Sleep Apnea in Exhaled Breath

Bettina Streckenbach, Martin Osswald, Stefan Malesevic, Renato Zenobi, Malcolm Kohler

Publication

Anal. Chem, 2021

Combination of Exhaled Breath Analysis with Parallel Lung Function and FeNO Measurements in Infants

Fabienne Decrue, Kapil Dev Singh, Amanda Gisler, Mo Awchi, Jiafa Zeng, Jakob Usemann, Pablo Sinues

Publication

Communications Medicine, 2021

Personalised therapeutic management of epileptic patients guided by pathway-driven breath metabolomics

Kapil Dev Singh, Martin Osswald, Victoria C. Ziesenitz, Mo Awchi, Jakob Usemann, Lukas L. Imbach, Malcolm Kohler, Diego García-Gómez, Johannes van den Anker, Urs Frey, Alexandre N. Datta, Pablo Sinues

Publication

Sleep Medicine, 2021

Validation of breath biomarkers for obstructive sleep apnea

Nora Nowak, Anna Engler, Sira Thiel, Anna S.Stöberl, Pablo Sinues, Renato Zenobi, Malcolm Kohler

Publication

J. Breath Res. 2020

Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by Secondary Electrospray Ionization-High Resolution Mass Spectrometry: Technical aspects

Gisler A, Lan J, Singh KD, Usemann J, Frey U, Zenobi R, Sinues P

Publication

Anal. Bio. Chem. 2019

Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry

Singh KD, Tancev G, Decrue F, Usemann J, Appenzeller R, Barreiro P, Jauma G, Macia Santiago M, Vidal de Miguel G, Frey U, Sinues P.

Publication

Chest Journal 2019

Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations

Gaugg MT, Nussbaumer-Ochsner Y, Bregy L, Engler A, Stebler N, Gaisl T, Bruderer T, Nowak N, Sinues P, Zenobi R, Kohler M

Publication

Respirology 2019

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis

Gaugg MT, Engler A, Bregy L, Nussbaumer-Ochsner Y, Eiffert L, Bruderer T, Zenobi R, Sinues P, Kohler M

Publication

J. Breath Res. 2018

Translating Secondary Electrospray Ionization–High Resolution Mass Spectrometry to the Clinical Environment

Singh KD, De Miguel GV, Gaugg MT, Ibanez AJ, Zenobi R, Kohler M, Frey U, Sinues PM-L

Publication

J. Breath Res. 2018

Real-time exhaled breath analysis in patients with cystic fibrosis and controls

Gaisl T, Bregy L, Stebler N, Gaugg MT, Bruderer T, Garcia-Gomez D, Moeller A, Singer F, Schwarz EI, Benden C, Sinues PM, Zenobi R, Kohler M

Publication

Clin. Mass Spectr. 2018

Real-time mass spectrometric identification of metabolites characteristic of chronic obstructive pulmonary disease in exhaled breath

Bregy L, Nussbaumer-Ochsner Y, Sinues PM-L, García-Gómez D, Suter Y, Gaisl T, Stebler N, Gaugg MT, Kohler M, Zenobi R.

Publication

Publications by Year

2023

Journal of Breath Research - iopscience, 2023

Prediction of systemic free and total valproic acid by off-line analysis of exhaled breath in epileptic children and adolescents

Mo Awchi, Kapil Dev Singh, Patricia E. Dill, Urs Frey, Alexandre N. Datta, and Pablo Sinues

Publication

2022

IJMS, 2022

Severe Obstructive Sleep Apnea Disrupts Vigilance-State-Dependent Metabolism

Felix Schmidt, Nora Nowak, Patrick Baumgartner, Thomas Gaisl, Stefan Malesevic, Bettina Streckenbach, Noriane A. Sievi, Esther I. Schwarz, Renato Zenobi, Steven A. Brown, Malcolm Kohler

Publication

Lung Cancer Journal, 2022

Mapping the landscape of lung cancer breath analysis: A scoping review

Felix Schmidt, Dario Kohlbrenner, Stefan Malesevic, Alice Huang, Sabine D. Klein, Milo A. Puhan, Malcolm Kohler

Publication

iScience, 2022

An interoperability framework for multicentric breath metabolomic studies.

Gisler A, Singh KD, Zeng J, Osswald M, Awchi M, Decrue F, Schmidt F, Sievi NA, Chen X, Usemann J, Frey U, Kohler M, Li X, Sinues P.

Publication

J. Breath Res. 2022

A gas-phase standard delivery system for direct breath analysis.

Streckenbach B, Sakas J, Perkins N, Kohler M, Moeller A, Zenobi R

Publication

iScience, 2022

Rapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites.

Gómez-Mejia A, Arnold K, Bär J, Singh KD, Scheier TC, Brugger SD, Zinkernagel AS, Sinues P.

Publication

Cells, 2022

Validating Discriminative Signatures for Obstructive Sleep Apnea in Exhaled Breath

Bettina Streckenbach, Martin Osswald, Stefan Malesevic, Renato Zenobi, Malcolm Kohler

Publication

2021

Metabolites MDPI

Real-Time Monitoring of Metabolism during Exercise by Exhaled Breath

Martin Osswald, Dario Kohlbrenner, Nora Nowak, Jörg Spörri, Pablo Sinues, David Nieman, Noriane Sievi, Johannes Scherr, Malcolm Kohler

Publication

Cell Reports, 2021

Rapid and reversible control of human metabolism by individual sleep states

N. Nowak, T. Gaisl, D. Miladinovic, R. Marcinkevics, M. Osswald, J. Buhmann, R. Zenobi, P. Sinues, S. A. Brown, M. Kohler

Publication

Chem. Commun. 2021

In vivo monitoring of volatile metabolic trajectories enables rapid diagnosis of influenza infection

Zhihong Yin, Wenbo Huang, Kapil Dev Singh, Zhaoming Chen, Xing Chen, Zhen Zhou, Zifeng Yang, Sinues P, Xue Li

Publication

Anal. Chem. 2021

Online Real-Time Monitoring of Exhaled Breath Particles Reveals Unnoticed Transport of Nonvolatile Drugs from Blood to Breath

Xing Chen,○ Keda Zhang,○ Zhihong Yin, Mingliang Fang, Weidan Pu, Zhening Liu, Lei Li,

Sinues P, Robert Dallmann, Zhen Zhou, and Xue Li*

Publication

2020

J. Breath Res. 2020

Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by Secondary Electrospray Ionization-High Resolution Mass Spectrometry: Technical aspects

Gisler A, Lan J, Singh KD, Usemann J, Frey U, Zenobi R, Sinues P

Publication

2019

Anal. Bioanal. Chem. 2019

Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry

Singh KD, Tancev G, Decrue F, Usemann J, Appenzeller R, Barreiro P, Jauma G, Macia Santiago M, Vidal de Miguel G, Frey U, Sinues P.

 

Publication

CHEST Journal 2019

Real-time breath analysis reveals specific metabolic signatures of COPD exacerbations

Gaugg MT, Nussbaumer-Ochsner Y, Bregy L, Engler A, Stebler N, Gaisl T, Bruderer T, Nowak N, Sinues P, Zenobi R, Kohler M

Publication

Respirology 2019

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis

Gaugg MT, Engler A, Bregy L, Nussbaumer-Ochsner Y, Eiffert L, Bruderer T, Zenobi R, Sinues P, Kohler M

 

Publication

2018

J. Breath Res. 2018

Translating Secondary Electrospray Ionization–High Resolution Mass Spectrometry to the Clinical Environment

Singh KD, De Miguel GV, Gaugg MT, Ibanez AJ, Zenobi R, Kohler M, Frey U, Sinues PM-L

Publication

J. Breath Res. 2018

Real-time exhaled breath analysis in patients with cystic fibrosis and controls

Gaisl T, Bregy L, Stebler N, Gaugg MT, Bruderer T, Garcia-Gomez D, Moeller A, Singer F, Schwarz EI, Benden C, Sinues PM, Zenobi R, Kohler M

Publication

Clin. Mass Spectrom. 2018

Real-time mass spectrometric identification of metabolites characteristic of chronic obstructive pulmonary disease in exhaled breath

Bregy L, Nussbaumer-Ochsner Y, Sinues PM-L, García-Gómez D, Suter Y, Gaisl T, Stebler N, Gaugg MT, Kohler M, Zenobi R.

Publication

Chest 2018

Real-time breath analysis reveals specific metabolic signature of COPD exacerbations

Gaugg M, Nussbaumer-Ochsner Y, Bregy L, Engler A, Stebler N, Gaisl T, Bruderer T, Nowak N, Sinues P, R, Zenobi, Kohler M

 

Publication

Sensors 2018

Guiding ketogenic diet with breath acetone sensors

Güntner AT, Kompalla JF, Landis H, Theodore SJ, Geidl B, Sievi NA, Kohler M, Pratsinis SE, Gerber PA

Publication

Anal. Chem 2018

Real-Time Monitoring of Tricarboxylic Acid Metabolics in Exhaled Breath

Tejero Rioseras A, Singh KD, Nowak N, Gaugg MT, Bruderer T, Zenobi R, Sinues PM-L

Publication

Clin. Mass Spectrom 2018

Real-time mass spectrometric identification of metabolites characteristic of chronic obstructive pulmonary disease in exhaled breath

Tejero Rioseras A, Singh KD, Nowak N, Gaugg MT, Bruderer T, Zenobi R, Sinues PM-L

Publication

2017

Analytical Chemistry 2017

Non-invasive body fat burn monitoring from exhaled acetone with Si-doped WO3 sensing nanoparticles

Güntner AT, Sievi NA, Theodore SJ, Gulich T, Kohler M, Pratsinis SE

 

Publication

Sci. Rep. 2017

Comprehensive Real-Time analysis of the Yeast Volatilome

Tejero Rioseras A, Garcia Gomez D, Ebert BE, Blank LM, Ibanez AJ, Sinues PM

 

Publication

Breath Res. 2017

Metabolic effects of inhaled salbutamol determined by exhaled breath analysis

Gaugg MT, Engler A, Nussbaumer-Ochsner Y, Bregy L, Stoberl AS, Gaisl T, Bruderer T, Zenobi R, Kohler M, Sinues PML

Publication

Meth. 2017

Secondary electrospray ionization proceeds via gas-phase chemical ionization

Rioseras AT, Gaugg MT, Sinues PML

Publication

Commun. 2017

Gauging circadian variation in ketamine metabolism by real-time breath analysis

Sinues PML, Kohler M, Brown SA, Zenobi R, Dallmann R.

Publication

Chem. 2017

Mass-Spectrometric Detection of Omega-Oxidation Products of Aliphatic Fatty Acids in Exhaled Breath

Gaugg MT, Bruderer T, Nowak N, Eiffert L, Sinues PML, Kohler M, Zenobi R

Publication

Food Control 2017

Rapid fingerprinting of grape volatile composition using secondary electrospray ionization orbitrap mass spectrometry: A preliminary study of grape ripening

Farrell RR, Fahrentrapp J, Garcia-Gomez D, Sinues PML, Zenobi R.

Publication

2016

Chemistry 2016

Real-time chemical analysis of E-cigarette aerosols by means of secondary electrospray ionization-mass spectrometry

Garcia-Gomez D, Gaisl T, Barrios Collado C, Vidal de Miguel G, Kohler M, Zenobi R.

Publication

CHIMIA Int. J. Chem. 2016

Real Time Read-Out of Plant Metabolism

Barrios-Collado C, García-Gómez D, Zenobi R, Vidal-de-Miguel G, Ibáñez AJ, Sinues PM-L.

Publication

Breath. Res. 2016

Expanding metabolite coverage of real-time breath analysis by coupling a universal secondary electrospray ionization source and high resolution mass spectrometry – a pilot study on tobacco smokers

Gaugg MT, Garcia Gomez D, Barrios Collado C, Vidal de Miguel G, Kohler M, Zenobi R, Sinues PML

 

Publication

Chem. 2016

Capturing in vivo plant metabolism by real time analysis of low to high molecular weight volatiles

Barrios-Collado C, García-Gómez D, Zenobi R, Vidal-de-Miguel G, Ibáñez AJ, Sinues PM-L

Publication

Sensors Actuators B: Chem. 2016

Numerical Modeling and Experimental Validation of a Universal Secondary Electrospray Ionization Source for Mass Spectrometric Gas Analysis in Real-Time

Barrios-Collado C, Vidal-de-Miguel G, Sinues PM-L

Publication

Thorax 2016

Effects of CPAP therapy withdrawal on exhaled breath pattern in obstructive sleep apnoea

Schwarz EI , Sinues PM-L , Bregy L, Gaisl T, Garcia Gomez D, Gaugg MT, Suter Y, Stebler N, Nussbaumer-Ochsner Y, Bloch KE, Stradling JR, Zenobi R, Kohler M

Publication

Chem. 2016

Real-Time Quantification of Amino Acids in the Exhalome by Secondary Electrospray Ionization–Mass Spectrometry: A Proof-of-Principle Study

García-Gómez D, Gaisl T, Bregy L, Cremonesi A, Sinues PM-L, Kohler M, Zenobi R

Publication

Comm. 2016

Secondary electrospray ionization coupled to high-resolution mass spectrometry reveals tryptophan pathway metabolites in exhaled human breath

Garcia-Gomez D, Gaisl T, Bregy L, Sinues PML, Kohler M, Zenobi R.

Publication

Future Oncology 2016

Noninvasive strategies for breast cancer early detection

Trecate G, Sinues PML, Orlandi R.

Publication

2015

Environ Sci Technol 2015

Detection and quantification of benzothiazoles in exhaled breath and exhaled breath condensate by real-time secondary electrospray ionizationhigh resolution mass spectrometry and ultra-high performance liquid chromatography

Garcia-Gomez D, Bregy L, Nussbaumer-Ochsner Y, Gaisl T, Kohler M, Zenobi R.

Publication

Angew. Chem. 2015

Drug pharmacokinetics determined by real-time analysis of mouse breath

Li X , Sinues PML , Dallmann R , Bregy L, Hollmen M, Proulx S, Brown SA, Detmar M, Kohler M., Zenobi R.

Publication

J. Breath. Res. 2015

Electrospray ionization-mass spectrometry and a novel statistical bioinformatic approach identifies a cancer related profile in exhaled breath of breast cancer patients: A pilot study

Sinues PML, Landoni E, Miceli R, Dibari VF, Dugo M, Agresti R, Tagliabue E, Cristoni S, Orlandi R.

Publication

Sci. Rep. 2015

Differentiation of dental bacteria in in vitro cultures and human saliva by secondary electrospray ionization – mass spectrometry

Bregy L, Muggler AR, Sinues PML, Garcia-Gomez D, Suter Y, Belibasakis GN, Kohler M, Schmidlin PR, Zenobi R.

Publication

Anal. Chem. 2015

Identification of 2-alkenals, 4-hydroxy-2-alkenals, and 4-hydroxy-2,6-alkadienals in exhaled breath condensate by UHPLC-HRMS and in breath by real-time HRMS

García-Gómez D, Martínez-Lozano Sinues P, Barrios-Collado C, Vidal-De-Miguel G, Gaugg M, Zenobi R.

Publication

2014

J. Clin. Pathol. 2014

Rapid identification of bacteria in blood cultures by mass-spectrometric analysis of volatiles

Ballabio C, Cristoni S, Puccio G, Kohler M, Sala MR, Brambilla P, Sinues PML

Publication

PLoS ONE 2014

Circadian variation of the human metabolome captured by real-time breath analysis

Sinues PML, Tarokh L, Li X, Kohler M, Brown SA, Zenobi R, Dallmann R.

Publication

Respiration 2014

Breath Analysis in Real Time by Mass Spectrometry in Chronic Obstructive Pulmonary Disease

Sinues PML, Meier L, Berchtold C, Ivanov M, Sievi N, Camen G, Kohler M, Zenobi R.

Publication

Anal. Meth. 2014

Real-time detection of chemical warfare agent simulants in forensic samples using active capillary plasma ionization with benchtop and field-deployable mass spectrometers

Dumlao M, Sinues PML, Nudnova M, Zenobi R.

Publication

Sci. Rep. 2014

Fingerprinting Breast Cancer vs. Normal Mammary Cells by Mass Spectrometric Analysis of Volatiles

He JJ, Sinues PML, Hollmen M, Li X, Detmar M, Zenobi R.

Publication

CHIMIA Int. J. Chem. 2014

Mass Spectrometry Research at the Laboratory for Organic Chemistry, ETH Zurich

Barylyuk K, Frankevich V, Ibanez AJ, Sinues PML, Zenobi R.

Publication

J. Anal. Chem. 2014

Ion mobility spectrometry coupled to laser-induced fluorescence for probing the electronic structure and conformation of gas-phase ions

Frankevich VE, Barylyuk KV, Sinues PML, Zenobi R

Publication

J. Breath Res. 2014

Real-time breath analysis with active capillary plasma ionization-ambient mass spectrometry

Bregy L, Sinues PML (corr. author), Nudnova MM, Zenobi R.

Publication

2013

CHEST Journal 2013

Analysis of the exhalome: A diagnostic tool of the future

Sinues PML, Kohler M, Zenobi R.

Publication

PLoS ONE 2013

Human Breath Analysis May Support the Existence of Individual Metabolic Phenotypes

Sinues PML, Kohler M, Zenobi R.

Publication

Anal. Chem. 2013

Monitoring Diurnal Changes in Exhaled Human Breath

Sinues PML, Kohler M, Zenobi R.

Publication

Anal. Chem. 2013

Ion mobility spectrometry coupled to laserinduced fluorescence

Frankevich V, Martinez-Lozano Sinues P, Barylyuk K, Zenobi R.

Publication

Metabolomics 2013

Differential mobility analysis-mass spectrometry coupled to XCMS algorithm as a novel analytical platform for metabolic profiling

Martínez-Lozano Sinues P, Criado E, Vidal G, Cristoni S, Franzoso F, Piatti M, Brambilla P

Publication

Reviews

Chemical Reviews 2019

Online analysis of exhaled breath

Bruderer T, Gaisl T, Gaugg M, Nowak N, Streckenbach B, Müller S, Moeller A, Kohler M, Zenobi R

Publication

J Breath Res 2018

Translating secondary electrospray ionization – high-resolution mass spectrometry to the clinical environment

Singh K, Vidal-de-Miguel G, Gaugg M, Ibáñez A, Zenobi R, Kohler M, Frey U, Sinues P

Publication

Exp Rev Resp Med 2017

Exhaled breath analysis in obstructive sleep apnea

Engler A, Schwarz EI, Kohler M

Publication